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The Surprising Connection Between Alzheimer’s and Gum Disease

June 3, 2025

An elderly man and woman with man looking forgetful.

In recent years, scientists have uncovered a startling link between oral health and brain health, specifically, a growing connection between gum disease and Alzheimer’s disease. While it may seem hard to imagine that bleeding gums could relate to memory loss, ongoing research shows that the inflammation and bacteria associated with periodontal disease may play a role in the development or progression of Alzheimer’s. Understanding this connection underscores the importance of maintaining good oral hygiene – not just for your smile, but for your brain as well.

Gum Disease Explained

Gum disease, also known as periodontal disease, is a chronic inflammatory condition that affects the soft tissue and bone supporting the teeth. It begins with gingivitis, characterized by red, swollen gums that may bleed easily. If left untreated, it can progress to periodontitis, where bacteria cause deep pockets between the gums and teeth, bone loss, and even tooth loss.

The main culprit is plaque, a sticky film of bacteria that forms on teeth. When not removed through proper brushing and flossing, plaque hardens into tartar and triggers inflammation in the gums. This inflammation doesn’t just stay in the mouth; it can enter the bloodstream and affect other parts of the body.

The Brain-Inflammation Connection

Chronic inflammation is a known risk factor for several serious diseases, including Alzheimer’s. One theory is that the bacteria from gum disease, especially Porphyromonas gingivalis, a harmful pathogen commonly found in advanced gum disease, can travel through the bloodstream or along cranial nerves to the brain.

Research has found P. gingivalis in the brain tissue of individuals with Alzheimer’s disease, suggesting a potential role in triggering or worsening the condition. These bacteria release toxic enzymes called gingipains, which may damage brain cells and promote the accumulation of beta-amyloid plaques, a hallmark of Alzheimer’s disease.

Additionally, the body’s immune response to oral bacteria can lead to long-term inflammation that may contribute to the breakdown of brain neurons over time.

Shared Risk Factors

Gum disease and Alzheimer’s also share several common risk factors, including age, smoking, diabetes, poor diet, and low socioeconomic status. These overlapping risk factors make it even more important to manage oral health as part of a holistic approach to preventing cognitive decline.

Furthermore, individuals with cognitive impairment may struggle to maintain daily oral hygiene, creating a feedback loop where poor dental care exacerbates health problems, including further cognitive decline.

What You Can Do

The potential link between gum disease and Alzheimer’s is still being explored, but the evidence is strong enough to suggest that maintaining good oral hygiene is vital for more than just your teeth. Here are a few ways to protect both your smile and your brain:

  • Brush twice a day and floss daily.
  • Visit your dentist regularly for cleanings and checkups.
  • Avoid smoking and manage chronic health conditions like diabetes.
  • Eat a balanced, low-sugar diet to support oral and overall health.

While gum disease and Alzheimer’s disease might seem unrelated at first glance, emerging science reveals a meaningful connection through inflammation, bacterial migration, and shared risk factors. By prioritizing oral hygiene, you may be taking a critical step not only toward a healthier mouth but also a healthier mind.

About the Author

Dr. Tavi Henry is a graduate of the University of Colorado School of Dental Medicine. His education didn’t end there, though – to date, Dr. Henry has logged 400 hours of continuing education on subjects such as sleep dentistry, cosmetic restorations, implant dentures, and orthodontics. He also maintains membership in organizations including the American Dental Association, the American Academy of Cosmetic Dentistry, and the Academy of General Dentistry. If you’re experiencing symptoms of gum disease, Dr. Henry and our team would be happy to treat you. Schedule your appointment online or call (303) 984-1400.